Análisis segmentario del pelo para detectar la exposición crónica a drogas psicoactivas

This study presents the case of a 4-year-old healthy child admitted to the paediatric ward for suspected accidental intoxication due to ingestion of narcoleptic drugs (methylphenidate, sertraline and quetiapine), taken on a regular basis by his 8-year-old brother affected by Asperger syndrome. Intox...

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Bibliographic Details
Published inAdicciones (Palma de Mallorca) Vol. 28; no. 3; p. 158
Main Authors Marchei, Emilia, Palmi, Ilaria, Pichini, Simona, Pacifici, Roberta, Anton Airaldi, Ileana-Rita, Costa Orvay, Juan Antonio, García Serra, Joan, Bonet Serra, Bartolomé, García-Algar, Óscar
Format Journal Article
LanguageEnglish
Spanish
Published Palma de Mallorca Socidrogalcohol 01.07.2016
Subjects
Antidepressants
Drug testing
Hair
Immunoassay
Poisoning
Psychotropic drugs
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Summary:This study presents the case of a 4-year-old healthy child admitted to the paediatric ward for suspected accidental intoxication due to ingestion of narcoleptic drugs (methylphenidate, sertraline and quetiapine), taken on a regular basis by his 8-year-old brother affected by Asperger syndrome. Intoxication can be objectively assessed by measurements of drugs and metabolites in biological matrices with short-term (blood and urine) or long-term (hair) detection windows. At the hospital, the childs blood and urine were analysed by immunoassay (conrmed by liquid chromatography-mass spectrometry), and sertraline and quetiapine and their metabolites were identied. The suspicion that the mother administered drugs chronically prompted the analysis of six, consecutive 2-cm segments of the childs hair, using ultra-high performance liquid chromatography-tandem mass spectrometry, thereby accounting for ingestion over the previous 12 months. Quetiapine was found in the rst four segments with a mean concentration of 1.00 ng/mg 0.94 ng/mg hair while sertraline and its metabolite, desmethyl-sertraline, were found in all segments with a mean concentration of 2.65 0.94 ng/mg and 1.50 0.94 ng/mg hair, respectively. Hair analyses were negative for methylphenidate and its metabolite (ritalinic acid). Biological matrices testing for psychoactive drugs disclosed both acute and chronic intoxication with quetiapine and sertraline administered by the mother.
ISSN:0214-4840
DOI:10.20882/adicciones.825