Efficient intraliposomal entrapment of hydrophilic platinum oligonuclear complexes

A simple method for intraliposomal entrapment of platinum complexes is presented, where hydrophilic platinum oligonuclear complexes, 1-methyluracil green (MeUG), uridine green (UdG) and uridine blue (UdB), are included inside liposomes and allowed to react with bilayer lipids. The liposomes prepared...

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Bibliographic Details
Published inJournal of the American Oil Chemists' Society Vol. 75; no. 12; pp. 1161 - 1166
Main Authors Ogawa, Yoshikatsu, Yamazaki, Yoshimitsu, Kodaka, Masato, Okuno, Hiroaki
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.12.1998
Springer-Verlag
Subjects
Intraliposomal entrapment
liposomes
platinum oligonuclear complex
tissue uptake of platinum complexes
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Summary:A simple method for intraliposomal entrapment of platinum complexes is presented, where hydrophilic platinum oligonuclear complexes, 1-methyluracil green (MeUG), uridine green (UdG) and uridine blue (UdB), are included inside liposomes and allowed to react with bilayer lipids. The liposomes prepared in this method exhibit higher entrapment efficiency and higher distribution to organs (liver, kidney, spleen, lung) and blood (but not B16 cancer cells) than those prepared from mononuclear Pt complexes [cis-diamminedichloroplatinum, cis-diammine-1,1'-dicarboxylatocyclobutaneplatinum, and cis-dichloro-cis-dihydroxy-trans-bis(isopropylamine)platinum)].
Bibliography:http://dx.doi.org/10.1007/s11746-998-0306-2
ISSN:0003-021X
1558-9331
DOI:10.1007/s11746-998-0306-2