Efficient intraliposomal entrapment of hydrophilic platinum oligonuclear complexes
A simple method for intraliposomal entrapment of platinum complexes is presented, where hydrophilic platinum oligonuclear complexes, 1-methyluracil green (MeUG), uridine green (UdG) and uridine blue (UdB), are included inside liposomes and allowed to react with bilayer lipids. The liposomes prepared...
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Published in | Journal of the American Oil Chemists' Society Vol. 75; no. 12; pp. 1161 - 1166 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Berlin/Heidelberg : Springer-Verlag
01.12.1998
Springer-Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | A simple method for intraliposomal entrapment of platinum complexes is presented, where hydrophilic platinum oligonuclear complexes, 1-methyluracil green (MeUG), uridine green (UdG) and uridine blue (UdB), are included inside liposomes and allowed to react with bilayer lipids. The liposomes prepared in this method exhibit higher entrapment efficiency and higher distribution to organs (liver, kidney, spleen, lung) and blood (but not B16 cancer cells) than those prepared from mononuclear Pt complexes [cis-diamminedichloroplatinum, cis-diammine-1,1'-dicarboxylatocyclobutaneplatinum, and cis-dichloro-cis-dihydroxy-trans-bis(isopropylamine)platinum)]. |
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Bibliography: | http://dx.doi.org/10.1007/s11746-998-0306-2 |
ISSN: | 0003-021X 1558-9331 |
DOI: | 10.1007/s11746-998-0306-2 |