Potensi Ekstrak Etanol Ubi Jalar Ungu sebagai Inhibitor Angiotensin Converting Enzyme pada Tikus Hipertensi

• Published in: IJHN : Indonesian journal of human nutrition Vol. 8; no. 1; pp. 88 - 96
• Main Authors: Rahmawati, Irma Sarita, Soetjipto, Soetjipto, Catur Adi, Annis, Aulanni’am, Aulanni’am, Rizky Maulidiana, Annisa
• Format: Journal Article
• Language: English
• Published: University of Brawijaya 31.07.2021
• Subjects: ace-inhibitor; antihypertension; chlorogenic acid; doca–salt; purple sweet potato
• ISSN: 2442-6636; 2355-3987
• DOI: 10.21776/ub.ijhn.2021.008.01.9

There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanin found in purple sweet potato generates bioactive compound with antihypertensive and anti-ACE activities in RAA system. The present study sought to investigate anti-ACE activities in RAA system of extract ethanol of purple sweet potato (EP) in deoxycorticosterone acetate (DOCA–salt)–induced hypertensive rats (Rattus norvegicus). The rats were orally administrated a 95% ethanol extract of purple sweet potato (var. ayamurasaki) (EP) in a daily dose of 200 and 400 mg/kg body weight also chlorogenic acid (CA) of 700 mg/kg bw for 4 weeks. Activity of renin, ACE, and Ang II concentration were assessed. Inhibiting activity of renin, ACE, and decreasing Ang II concentration after treatment was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; (P<0.05). This is the first report that demonstrates the lowering of blood pressure and anti-ACE in RAA-system effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA–salt model of hypertension.