The Structure of the Left Ventricle Myocardium of Preterm Rats in the Early Postnatal Period

• Published in: Cell and tissue biology Vol. 16; no. 4; pp. 364 - 371
• Main Authors: Ivanova, V. V., Milto, I. V., Serebryakova, O. N., Sukhodolo, I. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2022; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Birth; Cardiovascular system; Cell Biology; Degranulation; Functional morphology; Gestation; Heart; Life Sciences; Myocardium; Pregnancy; Premature birth; Stroma; Ventricle; preterm birth; myocardium; fibrosis; rats; mast cells; structure
• ISSN: 1990-519X; 1990-5203
• DOI: 10.1134/S1990519X22040046

Preterm birth is positively correlated with a predisposition to the development of diseases of the cardiovascular system in adulthood. The identification of morphofunctional changes in the heart of prematurely born children in the early postnatal period is a high-priority task, as it will prevent or correct the development of long-term negative effects of prematurity on their cardiovascular system. Histological and morphometric analysis of the myocardium of the heart left ventricle of Wistar rats born on days 21 and 21.5 of pregnancy (the full gestation period is 22 days) was carried out. It has been shown that preterm birth increases the specific volume of rat myocardial stroma in the early postnatal period of ontogenesis. Preterm birth does not change the number and coefficient of mast-cell degranulation in the myocardium of the left ventricle in the rat heart. Morphological changes in the myocardium of preterm rats are more pronounced with a shorter gestation period (21 days of pregnancy).