Inhibitors of the Metabolism of Arachidonic Acid Suppress Ca2+ Responses Induced by Trifluoperazine in Macrophages
The influence of the neuroleptic trifluoperazine on the intracellular concentration of Ca 2+ in macrophages of rats was studied using a Fura-2AM fluorescent Ca 2+ probe. It was found that trifluoperazine causes a dose-dependent increase in the intracellular Ca 2+ concentration associated with Ca 2+...
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Published in | Cell and tissue biology Vol. 12; no. 4; pp. 315 - 322 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
2018
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The influence of the neuroleptic trifluoperazine on the intracellular concentration of Ca
2+
in macrophages of rats was studied using a Fura-2AM fluorescent Ca
2+
probe. It was found that trifluoperazine causes a dose-dependent increase in the intracellular Ca
2+
concentration associated with Ca
2+
mobilization from intracellular Ca
2+
stores and subsequent entry of Ca
2+
into peritoneal macrophages of rats. It was also shown that inhibitors of phospholipase A
2
(4-bromophenacyl bromide, prednisolone, and dexamethasone), cyclooxygenases (aspirin and indomethacin), and lipoxygenases (caffeic acid, zileuton, and baicalein) suppress Ca
2+
responses induced by trifluoperazine in macrophages. The data obtained indicate the participation of enzymes and/or products of the cascade of arachidonic acid metabolism in the influence of trifluoperazine on the intracellular concentration of Ca
2+
in peritoneal macrophages. |
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ISSN: | 1990-519X 1990-5203 |
DOI: | 10.1134/S1990519X18040065 |