Inhibitors of the Metabolism of Arachidonic Acid Suppress Ca2+ Responses Induced by Trifluoperazine in Macrophages

The influence of the neuroleptic trifluoperazine on the intracellular concentration of Ca 2+ in macrophages of rats was studied using a Fura-2AM fluorescent Ca 2+ probe. It was found that trifluoperazine causes a dose-dependent increase in the intracellular Ca 2+ concentration associated with Ca 2+...

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Published inCell and tissue biology Vol. 12; no. 4; pp. 315 - 322
Main Authors Milenina, L. S., Krutetskaya, Z. I., Naumova, A. A., Butov, S. N., Krutetskaya, N. I., Antonov, V. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2018
Springer Nature B.V
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Summary:The influence of the neuroleptic trifluoperazine on the intracellular concentration of Ca 2+ in macrophages of rats was studied using a Fura-2AM fluorescent Ca 2+ probe. It was found that trifluoperazine causes a dose-dependent increase in the intracellular Ca 2+ concentration associated with Ca 2+ mobilization from intracellular Ca 2+ stores and subsequent entry of Ca 2+ into peritoneal macrophages of rats. It was also shown that inhibitors of phospholipase A 2 (4-bromophenacyl bromide, prednisolone, and dexamethasone), cyclooxygenases (aspirin and indomethacin), and lipoxygenases (caffeic acid, zileuton, and baicalein) suppress Ca 2+ responses induced by trifluoperazine in macrophages. The data obtained indicate the participation of enzymes and/or products of the cascade of arachidonic acid metabolism in the influence of trifluoperazine on the intracellular concentration of Ca 2+ in peritoneal macrophages.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X18040065