Highly Porous Composite Hydrogel Materials Based on β-Ca3(PO4)2/Polyethylene Glycol Diacrylate

• Published in: Inorganic materials : applied research Vol. 13; no. 5; pp. 1290 - 1295
• Main Authors: Evdokimov, P. V., Kiseleva, A. K., Shibaev, A. V., Filippova, O. E., Novoseletskaya, E. S., Efimenko, A. Yu, Scherbakov, I. M., Shipunov, G. A., Dubrov, V. E., Putlayev, V. I.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2022; Springer Nature B.V
• Subjects: Biomedical materials; Calcium phosphates; Chemistry; Chemistry and Materials Science; Composite materials; Elastic properties; Hydrogels; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Materials for Human Life Support and Environmental Protection; Materials Science; Mechanical properties; Polyethylene glycol; Pore size; Porous materials; Stiffness; bone tissue regeneration; biomaterials; calcium phosphate; hydrogel; composite; macroporosity
• ISSN: 2075-1133; 2075-115X
• DOI: 10.1134/S2075113322050094

The possibility of obtaining highly porous hydrogel composite materials for biomedical applications based on tricalcium phosphate in a polyethylene glycol diacrylate matrix, aimed at repairing bone defects, has been studied. The effect of different content of inorganic filler particles exerted on the mechanical characteristics of highly porous hydrogel composites β-Ca 3 (PO 4 ) 2 /polyethylene glycol diacrylate has been studied. It is demonstrated that the preparation of highly porous composite materials with specified elastic properties is quite possible. The viscoelastic properties of the obtained materials are shown to depend on the preset pore size. Varying the tricalcium phosphate fraction in the highly porous hydrogel material makes it possible to control the relative stiffness of the composite.