Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites

Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for...

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Bibliographic Details
Published inArkhiv patologii Vol. 85; no. 1; p. 36
Main Authors Raskin, G A, Mukhina, M S, Kaurtseva, A S, Andreeva, Yu Yu, Zavalishina, L E, Protasova, A E, Orlova, R V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2023
Subjects
Brain Neoplasms - genetics
Colorectal Neoplasms - pathology
DNA
Humans
Microsatellite Instability
Microsatellite Repeats
microsatellite instability
mismatch repair system
immunohistochemistry
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Summary:Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for the appointment of therapy with immune checkpoint inhibitors. Immunohistochemistry is a reliable and available method for detecting a deficiency in the DNA mismatch repair system, and it has recommended as a screening for hereditary syndromes associated with microsatellite instability. This article discusses the advantages and disadvantages of this research method from the point of view of the practitioner.
ISSN:0004-1955
DOI:10.17116/patol20238501136