Evaluation of the Effectiveness and Reproducibility of Biological Models of Chronic Heart Failure

Chronic heart failure (CHF) has attracted the attention of researchers and doctors for a long time, because, unfortunately, the number of patients with this pathology grows every year. The study of the etiology, pathogenesis, treatment methods, and possible consequences of CHF is important for effec...

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Bibliographic Details
Published inBiology bulletin reviews Vol. 12; no. 6; pp. 661 - 666
Main Authors Bolotskikh, V. I., Makeeva, A. V., Lushchik, M. V., Mokasheva, Ek. N., Mokasheva, Ev. N., Shishkina, V. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2022
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Biology
Congestive heart failure
Drug development
Ecology
Edema
Etiology
Heart failure
Hypoxia
Life Sciences
Pathology
Physical activity
Reproducibility
Research methodology
Zoology
pharmacological models
myocardial hypertrophy
chronic heart failure
surgical models
biological modeling
isoproterenol
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Summary:Chronic heart failure (CHF) has attracted the attention of researchers and doctors for a long time, because, unfortunately, the number of patients with this pathology grows every year. The study of the etiology, pathogenesis, treatment methods, and possible consequences of CHF is important for effective therapy and prevention. Cardiac pathology is characterized by the appearance of shortness of breath, development of chronic fatigue, edema, decreased physical activity due to disruption of normal perfusion of organs and tissues, and the development of chronic hypoxia. In this regard, modeling of heart failure in animals seems to be very relevant and promising, as it makes it possible to study the etiopathogenetic features of the development of CHF and its complications in detail. The preclinical stage of the study of drugs on animals allows evaluation of the mechanism of action of the drug, choose the right dosage, and describe side effects. The use of small rodents in the creation of CHF models is less time-consuming and economically more feasible than conducting research on large animals. This article provides an analysis of the effectiveness and reproducibility of biological models of CHF. We describe the most common modern surgical and pharmacological models, experimental methods, crucial hemodynamic and histomorphological changes observed during the development of CHF in animals, and the disadvantages and advantages of different types of modeling.
ISSN:2079-0864
2079-0872
DOI:10.1134/S2079086422060020