A novel catalytic application of heteropolyacids： chemical transformation of major ginsenosides into rare ginsenosides exemplified by R_（g1）

High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry（HPLC-Q-TOF-MS）method was developed for analyzing the hydrolytic mixtures of ginsenoside R_（g1） in acidic conditions（pH 3）. Three catalysts, a heteropolyacid（H_4SiW_（12）O_（40）, SiW_（12） for short）, its comp...

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Bibliographic Details
Published in中国科学：化学英文版 Vol. 60; no. 6; pp. 748 - 753
Main Author Jie Cao Chang Liu Qianqian Wang Yuze Li Qing Yu
Format Journal Article
LanguageEnglish
Published 01.06.2017
Subjects
串联质谱法
人参皂苷
催化应用
化学转化
杂多酸
碎片离子
酸性条件
高效液相色谱-质谱法
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Summary:High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry（HPLC-Q-TOF-MS）method was developed for analyzing the hydrolytic mixtures of ginsenoside R_（g1） in acidic conditions（pH 3）. Three catalysts, a heteropolyacid（H_4SiW_（12）O_（40）, SiW_（12） for short）, its complex with γ-CD（SiW_（12）/γ-CD for short） and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW_（12）（≈SiW_（12）/γ-CD） is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.
Bibliography:High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry（HPLC-Q-TOF-MS）method was developed for analyzing the hydrolytic mixtures of ginsenoside R_（g1） in acidic conditions（pH 3）. Three catalysts, a heteropolyacid（H_4SiW_（12）O_（40）, SiW_（12） for short）, its complex with γ-CD（SiW_（12）/γ-CD for short） and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW_（12）（≈SiW_（12）/γ-CD） is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.
ginsenoside R_（g1） heteropolyacid hydrolysis HPLC-Q-TOF-MS
11-5839/O6
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-016-0439-6