Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model

• Published in: Dhaka University Journal of Pharmaceutical Sciences Vol. 14; no. 1; pp. 49 - 53
• Main Authors: Akter, Mansura, Saha, Sajal Kumar, Rahman, SM Abdur
• Format: Journal Article
• Language: English
• Published: 18.06.2015
• ISSN: 1816-1820; 1816-1839
• DOI: 10.3329/dujps.v14i1.23735

Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), ethyl ester, C16H17O3 (compound 2) and isopropyl ester, C17H20O3 (compound 3) were subjected to NSAID induced gastro-ulcergenecity studies on young, healthy male rat model. Rats (Rattus novergicus: Sprague-Dawley strain) of 2-months old weighing 95–105 g were administered with naproxen (10 mg/kg b.w.) compound 1 (10.609 mg/kg b.w.), compound 2 (11.217 mg/kg b.w.) and compound 3 (11.826 mg/kg b.w.) twice daily for 4.5 days. The naproxen esters appeared to induce significantly less GI injury and bleeding both in microscopic and macroscopic examinations. This study can be a basis of reference for further acute, chronic or subchronic toxicity studies in various in-vivo models.Dhaka Univ. J. Pharm. Sci. 14(1): 49-53, 2015 (June)