The new supra molecular nano-aggregate curcumin-cucurbit[7]uril: synthesis, photophysical properties and biocompatibility evaluation

The supramolecular nano-aggregate CUR-CB[7] (CUR = curcumin and CB[7] = cucurbit[7]uril) was efficiently prepared by mixing CUR. and CB[7] at a molar ratio of 1:1 in ethanol at room temperature. The supramolecular aggregate formation was evidenced by mainly FTIR, 1 H. NMR, DOSY. and spectroscopy exp...

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Bibliographic Details
Published inPhotochemical & photobiological sciences Vol. 16; no. 5; pp. 663 - 671
Main Authors de Azevedo, Leandro Araújo, da Luz, Leonis Lourenço, de Ferro, Jamylle Nunes Souza, Barreto, Emiliano, Silva, Ricardo Oliveira, Junior, Severino Alves, Alves, Iane Bezerra Vasconcelos
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.05.2017
Subjects
Biochemistry
Biomaterials
Chemistry
Physical Chemistry
Plant Sciences
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Summary:The supramolecular nano-aggregate CUR-CB[7] (CUR = curcumin and CB[7] = cucurbit[7]uril) was efficiently prepared by mixing CUR. and CB[7] at a molar ratio of 1:1 in ethanol at room temperature. The supramolecular aggregate formation was evidenced by mainly FTIR, 1 H. NMR, DOSY. and spectroscopy experiments. The supramolecular arrangement promotes the increase in the solubility and stability of CUR. without affecting the biological properties of the A549 cells. The luminescence properties of CUR. and CUR-CBI7] show anti-Kasha’s rule fluorescence, and their remarkable NIR. emission enables this material to be used as a luminescent probe and marker for in vivo tracking and structural integrity monitoring of the supramolecular complex.
ISSN:1474-905X
1474-9092
DOI:10.1039/c6pp00408c