Does prostate weight influence time to biochemical recurrence in patients with cancer submitted to radical prostatectomy?

• Published in: Pathology Vol. 46; p. S136
• Main Authors: Billis, Athanase, Freitas, Leandro L.L., Mota, Marcelo V.B., de Angelis, Camila M., Carvalho, Kelson R., Reis, Leonardo O.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2014
• ISSN: 0031-3025; 1465-3931
• DOI: 10.1097/01.PAT.0000454561.44704.fa

It is controversial whether prostate weight is predictive of time to biochemical recurrence (TBCR) after radical prostatectomy. The study was based on 383 patients. Biochemical recurrence was considered as PSA 0.2 ng/mL or greater. TBCR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter TBCR using univariate and multivariate Cox proportional hazards model. Larger prostates were significantly associated with older patients and higher preoperative PSA level. Smaller prostates were associated with higher pathologic Gleason score and more extensive tumors. Prostate weight was not associated with race, clinical stage, biopsy Gleason score, positive surgical margins (PSM), extraprostatic extension (EPE), and seminal vesicle invasion (SVI). Comparing larger vs smaller prostates using the median value (35g), there was no significant difference associated with TBCR after surgery. Using univariate Cox proportional hazards model, preoperative PSA level, biopsy and pathologic Gleason score, tumor extent in surgical specimens, PSM, EPE, and SVI were significantly predictive of shorter TBCR. Prostate weight was not significantly predictive of shorter TBCR. On multivariate analysis, only PSM, SVI, and preoperative PSA level were independent predictors. Prostate weight is not significantly associated with or predictive of shorter time to biochemical recurrence after radical prostatectomy.