Comparative analysis of genetic variants of the HIV-1 circulating in the Irkutsk region in 1999 and 2012

• Published in: Voprosy virusologiĭ Vol. 61; no. 3; pp. 112 - 118
• Main Authors: Lebedev, A. V., Neshumaev, D. A., Kazennova, E. V., Lapovok, I. A., Laga, V. Yu, Tumanov, A. S., Glushchenko, N. V., Plotnikova, Yu. K., Ponomareva, O. A., Yarygina, E. I., Bobkova, M. R.
• Format: Journal Article
• Language: English
• Published: 28.06.2016
• ISSN: 0507-4088; 2411-2097
• DOI: 10.18821/0507-4088-2016-61-3-112-118

The pol and env genome regions of the HIV-1 genetic variants circulating in the irkutsk region of russia in 1999 and 2012 were compared. The results of this work showed the dominance of the HIV-1 subtype a IDU-A genetic variant (100%) in this region. No primary resistance mutations in the pol gene in the treatment-naive patients were found. The heterogeneity of the viral population was found to be significantly increased based on the pol and env analysis among HIV-variants isolated in 2012 (12.88% and 2.16%) from the intravenous drug users as compared to HIV-variants that caused the outbreak of the HIV infection in 1999 (1.64% and 0.47%). In addition, the comparison of genetic distances of the pol and env gene sequences in the viruses isolated in 2012 from the HIV-positive persons infected through heterosexual intercourse and intravenous drug use demonstrated that the transmission route influenced the variability of the virus population. Among the viruses of IDU-A variant circulating in the area in 2012 the prevalence of X4-tropic variants was 24.7%.