Prostate Cancer: Germline Mutations in BRCA1 and BRCA2

Genetic alterations are one of the important known risk factors of Prostate cancer. The family predisposition of breast and ovarian cancers may cause the lethal progression of familial prostate cancer in some men. The Association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer...

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Bibliographic Details
Published inAsian Pacific journal of cancer biology Vol. 8; no. 1; pp. 69 - 73
Main Authors Umarane, Pankaja, Ghagane, Shridhar C, Nerli, Rajendra
Format Journal Article
LanguageEnglish
Published West Asia Organization for Cancer Prevention 16.03.2023
Subjects
prostate cancer, mutations, brca1 and brca2
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Summary:Genetic alterations are one of the important known risk factors of Prostate cancer. The family predisposition of breast and ovarian cancers may cause the lethal progression of familial prostate cancer in some men. The Association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these pathogenic variants have a higher risk of causing prostate cancer. This study focused on the analysis of mutations causing prostate cancer around the world, associated with breast cancer susceptibility genes.
ISSN:2538-4635
2538-4635
DOI:10.31557/apjcb.2023.8.1.69-73