In-Silico Analysis of the BDNF (Brain Derived Neurotrophic Factor) Protein of Pigeon (Columba livia)

• Published in: EduChemia Vol. 5; no. 1; pp. 20 - 28
• Main Authors: Kirana, Ni Gusti Ayu Galuh Candra, Budiarsa, I Made, Kundera, I Nengah, Jamhari, Mohammad
• Format: Journal Article
• Language: English; Indonesian
• Published: Universitas Sultan Ageng Tirtayasa 30.01.2020
• Subjects: bdnf; homology; three dimensional of protein
• ISSN: 2502-4779; 2502-4787
• DOI: 10.30870/educhemia.v5i1.6763

BDNF protein plays a role in the growth and survival of neurons. BDNF protein has some uniqueness , and information on this protein is still limited reported , especially in pigeons. The purpose of this study is to predict the three-dimensional structure of the pigeon of  BDNF protein, to provide information in understanding the characteristics, structure of the protein using a homology approach through in-silico analysis. The BDNF protein is predicted using the SWISS-MODEL server and visualizing the prediction results on the CHIMERA Software. Pigeon BDNF protein was taken from Uniprot with a B4Z8Q access code with a template of 1b8m. 1. The analysis shows that BDNF protein has  an identity of 93,20% consisting of 226 amino acids with a target QMEAN value of -0.17 and hydrophobic amino acids namely Trp, His, Tyr, Ile, Leu, Gly, Lys, Cys, Ala, Phe, Met, and Val. Carboxyl residues , namely Glu, Asp and Val, and amine residues , namely Lys and Ser, with 82 hydrogen bonds.