A Case of Increased Creatin Kinase Level Caused by Daptomycin

• Published in: Haydarpașa Numune Hastanesi tıp dergisi = The medical journal of Haydarpașa Numune Hospital Vol. 60; no. 4; p. 445
• Main Author: Çakar, Zeynep Şule
• Format: Journal Article
• Language: English
• Published: Istanbul Kare Publishing 01.01.2020
• Subjects: Bacteria; Gram-positive bacteria; Muscle pain; Penicillin; Staphylococcus infections; Streptococcus infections
• ISSN: 1300-6363
• DOI: 10.14744/hnhj.2018.55477

Daptomycin is a fermentation product produced by Streptomyces roseosporus, which can act on aerobic and anaerobic gram-positive bacteria in its cyclic form. Daptomycin has activity against methicillin-resistant Staphylococcus aureus (MRSA), glycopeptide-intermediate Staphylococcus aureus, coagulase-negative staphylococcus species, penicillin-resistant Streptococcus pneumoniae, enterococci, vancomycin-resistant bacteria such as Pediococcus, Leuconostoc and Lactobacillus, gram positive anaerobic bacteria including Clostridium difficile, Corynebacterium and Bacillus bacteria and peptostreptococci. The primary toxicity associated with daptomycin is myopathy, which is rare. Muscle pain, muscle weakness and increased creatine kinase (CK) levels (MM isoenzyme) are detected due to myopathy. Paresthesia and reversible paralysis can be observed infrequently. In this article, a case of daptomycin-associated creatine phosphokinase elevation is presented. Clinical signs and symptoms improved with normal CK levels after discontinuation of daptomycin. Myopathy should be kept in mind in case of sudden muscle pain and high CK levels during the treatment with daptomycin.