Developmental Gene Expression of Trypsinogen and Lipase in Human Fetal Pancreas

Background: Very few studies have been reported on the expression of human pancreatic genes during fetal development. We have shown very low lipase immunoreactivity compared with elevated trypsinogen immunoreactivity in a previous immunohistological study of human fetal pancreas during development....

Full description

Saved in:
Bibliographic Details
Published inJournal of pediatric gastroenterology and nutrition Vol. 24; no. 1; pp. 63 - 67
Main Authors Moriscot, Christine, Renaud, Wanda, Carrère, Jacqueline, Figarella‐Branger, Dominique, Figarella, Catherine, Guy‐Crotte, Odette
Format Journal Article
LanguageEnglish
Published 01.01.1997
Subjects
Fetus, Dot blot
Gene expression
Human
Lipase
Pancreas
Trypsinogen
Online AccessGet full text

Cover

More Information
Summary:Background: Very few studies have been reported on the expression of human pancreatic genes during fetal development. We have shown very low lipase immunoreactivity compared with elevated trypsinogen immunoreactivity in a previous immunohistological study of human fetal pancreas during development. Methods: The expression of these two selectively expressed genes of the exocrine pancreas, trypsinogen and lipase were investigated. The developmental profiles of the corresponding mRNA's were determined from the 13th gestational week. Results: For the two genes, fetal mRNA levels throughout gestation remained significantly lower than the corresponding adult levels. No correlation was found between trypsinogen and lipase gene expression in the fetal pancreas, whereas such a correlation was present in adult pancreas. This may be explained by differences in maturity of the pancreas.
ISSN:0277-2116
1536-4801
DOI:10.1002/j.1536-4801.1997.tb01453.x