Warfarin Induced Necrosis of The Breast: A Case Report

Background: Warfarin induced breast necrosis is a rare complication of oral anticoagulant therapy. Although it can be related to protein C, S, and antithrombin III deficiency; the pathogenesis of necrosis is still unknown. Case presentation: We report a case of a 38-year-old woman with extensive lef...

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Bibliographic Details
Published inArchives of breast cancer pp. 189 - 191
Main Authors Zand, Sanaz, Jalili, Roghayye, Emami Razavi, Seyed Hasan, Najafi, Massoome, Kaviani, Ahmad
Format Journal Article
LanguageEnglish
Published Kaviani Breast Disease Institute 30.11.2018
Subjects
Breast gangrene
Breast necrosis
Oral anticoagulant therapy
Warfarin
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Summary:Background: Warfarin induced breast necrosis is a rare complication of oral anticoagulant therapy. Although it can be related to protein C, S, and antithrombin III deficiency; the pathogenesis of necrosis is still unknown. Case presentation: We report a case of a 38-year-old woman with extensive left breast necrosis after receiving warfarin for treatment of deep vein thrombosis. Simple mastectomy was performed and the wound was closed secondarily with an abdominal advancement flap. Rivaroxaban was prescribed after discontinuation of warfarin. Conclusion: Although breast necrosis following warfarin usage is uncommon, it should be considered in women presenting with breast symptoms after initiation of warfarin. Early diagnosis and appropriate management are essential to prevent extensive loss of breast tissue.
ISSN:2383-0425
2383-0433
DOI:10.32768/abc.201854189-191