A study on in vitro antioxidant effect of Cordyceps neovolkiana DL0004 extracts isolated in Lam Dong, Vietnam

Cordyceps neovolkiana DL0004 is a group of insect parasitic fungi collected at an altitude of 1650 m above sea level at the top of Langbiang Mountain, Lam Dong province, Vietnam. C. neovolkiana DL0004 has been used in traditional medicine and possesses numerous biological effects such as anti-cancer...

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Bibliographic Details
Published inVietnam Journal of Science, Technology and Engineering Vol. 65; no. 2; pp. 65 - 70
Main Authors Lam, Khac Ky, Nguyen, Thi Bao Tran, Nguyen, Thi Huynh Nhu, Le, Thi Thanh Lai, Dam, Sao Mai, Dinh, Minh Hiep, Ngo, Dai Hung
Format Journal Article
LanguageEnglish
Published Vietnam Ministry of Science and Technology 15.06.2023
Subjects
antioxidant
Cordyceps neovolkiana
reducing power
scavenging free radicals
xanthine oxidase inhibitors
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Summary:Cordyceps neovolkiana DL0004 is a group of insect parasitic fungi collected at an altitude of 1650 m above sea level at the top of Langbiang Mountain, Lam Dong province, Vietnam. C. neovolkiana DL0004 has been used in traditional medicine and possesses numerous biological effects such as anti-cancer, anti-inflammation, antioxidant properties. In this research, the fungi biomass and fruiting body of C. neovolkiana DL0004 were cultured and examined for their antioxidant properties using test methods such as reducing power, scavenging 2,2’-diphenyl-1-picrylhydrazyl (DPPH) free radical, neutralizing 2,2’-azinobis(3-ethylbenzothiazonline-6-sulfonate (ABTS) free radical, and inhibiting xanthine oxidase (XO). The results showed that all 7 extracts of the biomass were more active than the fruiting bodies of C. neovolkiana DL0004. Furthermore, the ethyl acetate (EtOAc) extract of C. neovolkiana DL0004 biomass showed DPPH, ABTS, and XO free radical scavenging with IC50 values (the concentration of the sample required to inhibit 50% of radical) of 107.01 μg/ml, 111.91 μg/ml, and 106.2248 μg/ml, respectively. Moreover, the reducing power of the EtOAc from C. neovolkiana DL0004 biomass was 0.184 at 1000 μg/ml.From the obtained results, the biomass EtOAc fraction extract of C. neovolkiana DL0004 was demonstrated to contain antioxidant compounds with potential applications in the production of functional foods.
ISSN:2525-2461
2615-9937
DOI:10.31276/VJSTE.65(2).65-70