Expression and Function of Na + HCO 3 − Cotransporters in the Gastrointestinal Tract
A bstract : The stomach, duodenum, colon, and pancreas secrete HCO 3 − ions into the lumen. Although the importance of HCO 3 − secretion for the maintenance of mucosal integrity, a normal digestion, and the reabsorption of Cl − has been well established, the molecular nature of the apical and basola...
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Published in | Annals of the New York Academy of Sciences Vol. 915; no. 1; pp. 1 - 14 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.12.2000
|
Online Access | Get full text |
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Summary: | A
bstract
:
The stomach, duodenum, colon, and pancreas secrete HCO
3
−
ions into the lumen. Although the importance of HCO
3
−
secretion for the maintenance of mucosal integrity, a normal digestion, and the reabsorption of Cl
−
has been well established, the molecular nature of the apical and basolateral HCO
3
−
transporting proteins has remained largely unknown. Functional studies have suggested that a Na
+
HCO
3
−
cotransport system, similar but not identical to the well‐characterized Na
+
HCO
3
−
cotransporter in the basolateral membrane of the kidney proximal tubule, is present in duodenal and colonic enterocytes, pancreatic ducts cells, and gastric cells and involved in HCO
3
−
uptake from the interstitium. This report describes our work towards understanding the molecular nature, cellular origin, and functional relevance of the Na
+
HCO
3
−
cotransporter(s) in the stomach and intestine and reviews work by others on the function and localization of Na
+
HCO
3
−
cotransport processes in the gastrointestinal tract. |
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ISSN: | 0077-8923 1749-6632 |
DOI: | 10.1111/j.1749-6632.2000.tb05219.x |