Role of single dose prophylactic antibiotic in elective caesarean section

• Published in: Bangabandhu Sheikh Mujib Medical University journal Vol. 6; no. 1; pp. 11 - 15
• Main Authors: Pervin, Hasna Hena, Kazal, Rezaul Karim, Begum, Kazi Farhana, Islam, Nilufar, Rahman, Reefat, Ara, Rowshan, Noor, Farah
• Format: Journal Article
• Language: English
• Published: Bangabandhu Sheikh Mujib Medical University 04.08.2016
• Subjects: Antibiotic; Caesarean section; Prophylactic
• ISSN: 2074-2908; 2224-7750
• DOI: 10.3329/bsmmuj.v6i1.29013

Background: Maternal morbidity related to infection after caesarean section has been reported to be higher than that of vaginal delivery. The prevention of infection in patients undergoing caesarean section is a major challenge, particularly in hospitals, where there is frequent chance of cross infection due to overcrowding. Objective: The present study was undertaken to see the efficacy of single dose cetriaxone as a prophylaxis in elective caesarean section to prevent postop­erative infection. Methods: This cross sectional study was conducted on 100 patients who underwent elective caesarean section where single dose of Ceftriaxone was used as prophylaxis in the Department of Obstetrics & Gynaecology, Bang­abandhu Sheikh Mujib Medical University Hospital, between January to June 2010. The outcomes measures were post­operative febrile morbidity, wound infe-ction and other infections (urinary tract infection, chest infection). Data were analysed using statistical package for social sciences (SPSS) version 11.5.Results: Over one-third (38%) patients age group was between 18 -25 years, 56% in between 25 -35 years and 6% were over 35 years old. Nearly half(46%) was anemic (haemoglobin< 11 g/dl) and 16% was obese (BMI?28 kg/m2). All the patients were operated by obstetricians of same level. Three per cent patients developed wound infection, 5% developed other infections like UTI and chest infection and 7% had febrile illness. Among the several factors suspected to be associated with post operative complications, preoperative anaemia, long duration of operation (>60 minutes) and prolonged hospital stay (>1 week) were found to be significantly assocated with postoperative complications.Conclusion: The present study suggests that single dose prophylactic antibiotic ceftriaxone given 1 hour before operation in patients with cesarean section deliveries reduces the chance of postoperative infection to a bare minimum.