Multifunctional Magnetic CuS/Gd 2 O 3 Nanoparticles for Fluorescence/Magnetic Resonance Bimodal Imaging-Guided Photothermal-Intensified Chemodynamic Synergetic Therapy of Targeted Tumors

• Published in: ACS applied materials & interfaces Vol. 14; no. 30; pp. 34365 - 34376
• Main Authors: Luo, Minchuan, Yukawa, Hiroshi, Sato, Kazuhide, Tozawa, Makoto, Tokunaga, Masato, Kameyama, Tatsuya, Torimoto, Tsukasa, Baba, Yoshinobu
• Format: Journal Article
• Language: English
• Published: United States 03.08.2022
• Subjects: Animals; Cell Line, Tumor; Copper; Hydrogen Peroxide; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy; Mice; Nanoparticles - therapeutic use; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Photothermal Therapy; Reactive Oxygen Species; Tumor Microenvironment; magnetic resonance imaging; enhanced chemodynamic therapy; fluorescence imaging; copper sulfide; photothermal therapy
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.2c06503

Chemodynamic therapy (CDT), which consumes endogenous hydrogen peroxide (H O ) to generate reactive oxygen species (ROS) and causes oxidative damage to tumor cells, shows tremendous promise for advanced cancer treatment. However, the rate of ROS generation based on the Fenton reaction is prone to being restricted by inadequate H O and unattainable acidity in the hypoxic tumor microenvironment. We herein report a multifunctional nanoprobe (BCGCR) integrating bimodal imaging and photothermal-enhanced CDT of the targeted tumor, which is produced by covalent conjugation of bovine serum albumin-stabilized CuS/Gd O nanoparticles (NPs) with the Cy5.5 fluorophore and the tumor-targeting ligand RGD. BCGCR exhibits intense near-infrared (NIR) fluorescence and acceptable relaxivity (∼15.3 mM s ) for both sensitive fluorescence imaging and high-spatial-resolution magnetic resonance imaging of tumors in living mice. Moreover, owing to the strong NIR absorbance from the internal CuS NPs, BCGCR can generate localized heat and displays a high photothermal conversion efficiency (30.3%) under 980 nm laser irradiation, which enables photothermal therapy and further intensifies ROS generation arising from the Cu-induced Fenton-like reaction for enhanced CDT. This synergetic effect shows such an excellent therapeutic efficacy that it can ablate xenografted tumors . We believe that this strategy will be beneficial to exploring other advanced nanomaterials for the clinical application of multimodal imaging-guided synergetic cancer therapies.