Unprecedented Multicomponent Reaction of Indoles, CS 2 and Nitroarenes: Stereoselective Synthesis of (Z)-3-((Arylamino)methylene)indoline-2-thiones

An efficient method for the stereoselective synthesis of (Z)-3-((arylamino)methylene)indoline-2-thiones have been developed via a novel multicomponent reaction of indoles, CS and nitroarenes. A range of functionalized indoline-2-thiones were prepared in moderate to good yields from easily available...

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Bibliographic Details
Published inChemistry, an Asian journal Vol. 16; no. 23; pp. 3890 - 3894
Main Authors Qin, Qi, Liu, Xin-Lian, Ma, Ai-Jun, Zhang, Xiang-Zhi, Peng, Jin-Bao
Format Journal Article
LanguageEnglish
Published Germany 01.12.2021
Subjects
C1 Synthon
Indoline-2-thiones
CS2
Nitroarenes
Multicomponent Reaction
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Summary:An efficient method for the stereoselective synthesis of (Z)-3-((arylamino)methylene)indoline-2-thiones have been developed via a novel multicomponent reaction of indoles, CS and nitroarenes. A range of functionalized indoline-2-thiones were prepared in moderate to good yields from easily available starting materials. The indoline-2-thione products can be easily derivatized to give biologically active thieno[2,3-b]indole and thiopyrano[2,3-b]indole skeletons in high yields.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202101008