Back Cover: A Click Chemistry‐Based Artificial Metallo‐Nuclease (Angew. Chem. Int. Ed. 38/2023)

A new click chemistry generated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC‐Thio is demonstrated. Copper‐TC‐Thio binds in the minor groove of genomic DNA a...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 62; no. 38
Main Authors Gibney, Alex, de Paiva, Raphael E. F., Singh, Vandana, Fox, Robert, Thompson, Damien, Hennessy, Joseph, Slator, Creina, McKenzie, Christine J., Johansson, Pegah, McKee, Vickie, Westerlund, Fredrik, Kellett, Andrew
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 18.09.2023
EditionInternational ed. in English
Subjects
Chemical synthesis
Copper
Damage
DNA damage
Grooves
Ligands
Metallography
Nuclease
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Summary:A new click chemistry generated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC‐Thio is demonstrated. Copper‐TC‐Thio binds in the minor groove of genomic DNA and promotes damage via a superoxide linked mechanism. The inset picture shows copper ions, bound to the TC‐Thio ligand, melting into the DNA duplex and filling the reaction chamber with molten liquid DNA.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202310432