2104-P: Serum Phosphorus Levels Are Associated with the Metabolic Syndrome and Adiponectin Levels in Nondiabetic Women with Normal Kidney Function

• Published in: Diabetes (New York, N.Y.) Vol. 68; no. Supplement_1
• Main Authors: NATSUKI, YUKA, MORIOKA, TOMOAKI, KAKUTANI, YOSHINORI, YAMAZAKI, YUKO, KURAJOH, MASAFUMI, MORI, KATSUHITO, FUKUMOTO, SHINYA, SHIOI, ATSUSHI, SHOJI, TETSUO, IMANISHI, YASUO, EMOTO, MASANORI, INABA, MASAAKI
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2019
• Subjects: Adiponectin; Calcium metabolism; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Epidermal growth factor receptors; Kidneys; Metabolic syndrome; Multivariate analysis; Phosphorus; Plasma; Population studies; Womens health
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db19-2104-P

Recent basic studies indicate that adiponectin, a key factor in the metabolic syndrome (MetS), directly regulates calcium (Ca)-phosphorus (P) metabolism. Previous studies indicate that serum P levels are inversely associated with the MetS in the general population. In this study, we investigated the association of serum P levels with the MetS and plasma adiponectin levels in both type 2 diabetes patients (T2D) and nondiabetic individuals (non-DM). We included 487 subjects with normal kidney function (eGFR ≥ 60 mL/min/1.73m2), including 285 T2D and 202 non-DM. The MetS was diagnosed according to the criteria of AHA/NHLBI. The medians of plasma adiponectin level and serum P level in the total population were 6.6 µg/mL, 3.6 mg/dL, respectively. T2D had older age, greater BMI, higher P levels, lower adiponectin levels, and comparable serum Ca levels and eGFR compared to non-DM. The MetS was diagnosed in 31% of non-DM and in 77% of T2D. In non-DM, but not in T2D, serum P levels tended to be lower in subjects with MetS than those without MetS, and were significantly lower in those having multiple MetS components. Plasma adiponectin levels were lower in subjects with MetS than those without MetS in both groups. Serum P levels showed inverse correlation with a number of MetS-related parameters, among which adiponectin level was the strongest one (ρ=0.338, p<0.001), in non-DM, but not in T2D. Multivariate analysis revealed that serum P levels were positively associated with plasma adiponectin levels (β=0.257, p=0.009), independently of age, BMI, eGFR, and serum Ca levels in non-DM women. On the other hand, no association was found between serum P and adiponectin levels in T2D. These data indicate that serum P levels, which are lower in the MetS, are independently and positively associated with plasma adiponectin levels in non-DM women. This study suggests a direct relationship between adiponectin and serum P level in women, which may be dysregulated in T2D.