Hepatopulmonary syndrome: a rare manifestation of cirrhosis in patient with diencephalic obesity and nonalcoholic fatty liver disease after surgery for craniopharyngioma

We describe a 15-year girl, who developed panhypopituitarism and diencephalic obesity after surgical excision of craniopharyngioma, followed by nonalcoholic fatty liver disease and cirrhosis 5 years after surgery. Cirrhosis in this case manifested by hypoxia due to hepatopulmonary syndrome, and desp...

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Published inProblemy ėndokrinologii Vol. 67; no. 5; pp. 58 - 66
Main Authors Mazerkina, N. A., Savateev, A. N., Gorelyshev, S. K., Mariashev, S. A., Beregovskaya, S. A., Konovalov, A. N.
Format Journal Article
LanguageEnglish
Russian
Published 12.11.2021
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Summary:We describe a 15-year girl, who developed panhypopituitarism and diencephalic obesity after surgical excision of craniopharyngioma, followed by nonalcoholic fatty liver disease and cirrhosis 5 years after surgery. Cirrhosis in this case manifested by hypoxia due to hepatopulmonary syndrome, and despite cure of craniopharyngioma by surgery and radiosurgery treatment and adequate hormonal substitution therapy patient died 9 years after surgery. Growth hormone substitutional therapy in patients with hypopituitarism, and steatohepatitis may decrease liver triglyceride accumulation and prevent end-stage liver disease.
ISSN:0375-9660
2308-1430
DOI:10.14341/probl12723