The Oxford Classification of IgA nephropathy: A review of literature

IgA nephropathy is one of the commonest forms of primary glomerulonephritis in the world, most commonly among Asian population.  Though usually slowly progressive, it is one of the important causes of chronic renal failure. Abnormal IgA1 are formed which leads to formation of IgG antibodies which de...

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Bibliographic Details
Published inJournal of Pathology of Nepal Vol. 8; no. 1; pp. 1308 - 1312
Main Author Pant, Anil Dev
Format Journal Article
LanguageEnglish
Published Association of Clinical Pathologists of Nepal 03.04.2018
Subjects
Antibodies
Antigen
Hematuria
Immunofluorescence
Kidney
Nephropathy
Nephrotic
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Summary:IgA nephropathy is one of the commonest forms of primary glomerulonephritis in the world, most commonly among Asian population.  Though usually slowly progressive, it is one of the important causes of chronic renal failure. Abnormal IgA1 are formed which leads to formation of IgG antibodies which deposit in the mesangium.  It presents with synpharyngitic hematuria and can have variable histopathological patterns.  The Oxford classification was devised in order to categorize the histopathological patterns, correlate with clinical course and modify treatment accordingly.  Different histopathological criteria are assessed in the classification, which include mesangial proliferation (M), endocapilary proliferation (E), segmental sclerosis (S), and interstitial fibrosis/tubular atrophy (T).The classification has become widely accepted around the world but still needs further validation studies and incorporation of newer parameters. 
ISSN:2091-0797
2091-0908
DOI:10.3126/jpn.v8i1.19459