FRI0436 ARTICULAR AND PERIARTICULAR INFECTIOUS DISEASES: REVIEW AND ANALYSIS OF A COHORT IN A 3RD LEVEL HOSPITAL

• Published in: Annals of the rheumatic diseases Vol. 79; no. Suppl 1; pp. 815 - 816
• Main Authors: Dos Santos Sobrín, R., Pérez Gómez, N., Perez-Pampín, E., Souto Vilas, A., Mera Varela, A.
• Format: Journal Article
• Language: English
• Published: 01.06.2020
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2020-eular.4807

Background: Infectious diseases in Rheumatology are still a prevalent healthcare issue nowadays. Microbiological tests and early beginning of antibiotic treatment are basic supportive therapy for those patients. In some cases, surgery is needed and it can involve prognostic features. Objectives: To analyze prognostic factors related to articular and periarticular infectious diseases. Methods: Patients hospitalized between January and December 2019 in Rheumatology Service (CHUS) and diagnosed of articular or periarticular infectious disease were enrolled. Demographic, clinical and therapeutic data were collected. Stata 15.1 was used to perform statistical analysis. Results: 21 patients diagnosed of articular or periarticular infectious disease were included (138 patients hospitalized in 2019). Mean age was 57,3 years old (SD 18,2) and 76,2% were males. One cardiovascular risk factor was achieved, at least, by 71,4% (arterial hypertension the most frequent, followed by hypercholesterolemia and hyperuricemia). Gram positive cocci were identified in 76,2% of patients ( Staphylococcus aureus in 47,6%, only one case oxacillin-resistant). A concomitant rheumatic disease was present in 4 patients (2 suffer from gout). No statistical association was found between this topic and acute-phase reactants (APR), complication rates or days of hospitalization. At hospitalization time, mean values of erythrocyte sedimentation rate (ESR) were 65,6 mm (SD 30,8) and C-reactive protein (CRP) 11,7 mg/dl (SD 7,7). Both have a positive association with days of hospitalization (r ESR =0,282 r CRP =0,424) and further, ESR demonstrates a positive correlation with this topic (CI95% -0,009 to 0,723 p=0,05569). Only 3 patients needed adjuvant surgery (articular infectious diseases with higher APR values). Surgery demonstrates a relationship statistically significant with articular involvement (t=-3,72 p=0,00), higher hospitalization rates (t=-2,51 p=0,02) and complication rates (Chi2=4,67 p=0,03 as decease, recurrence, bacteriemia, aftermath or soft tissue abscess). Conclusion: Gout is the main rheumatic disease associated, in this study, to infectious diseases of musculoskeletal system. As opposed, to suffer a rheumatic disease isn’t associate to a bad prognostic (hospitalization or complication rates). Furthermore, this cohort shows us the high prevalence of cardiovascular risk factors related with these diseases (hyperuricemia as predecessor of gout). Surgery intensifies as the main bad prognostic factor regarding days of hospitalization, complication rates and higher APR. References: [1]Morbimortality in adult patients with septic arthritis: a three-year hospital-based study. Ferrand J, et al . BMC Infect Dis 2016 [2]Predictors of treatment failure and mortality in native septic arthritis. Maneiro JR, et al . Clin Rheum 2014 Disclosure of Interests: None declared