A Simple Method for Deprotection of the N- and O-Carbobenzoxy Groups and N-Methylation of the Desosamine Sugar Moiety of Ketolides

• Published in: Journal of antibiotics Vol. 58; no. 11; p. 679
• Main Authors: Iwaki, Tsutomu, Nomura, Takashi, Narukawa, Yukitoshi, Uotani, Koichi
• Format: Journal Article
• Language: English
• Published: Tokyo Nature Publishing Group 01.11.2005
• Subjects: Sugar

A simple synthetic method for deprotection of the N- and O-carbobenzoxy groups (Cbz) of the desosamine sugar moiety of ketolides is reported. This deprotection method is applicable to the synthesis of a variety of ketolide analogues with various 9-iminoether moieties in good to moderate yield. Among...