A Simple Method for Deprotection of the N- and O-Carbobenzoxy Groups and N-Methylation of the Desosamine Sugar Moiety of Ketolides
A simple synthetic method for deprotection of the N- and O-carbobenzoxy groups (Cbz) of the desosamine sugar moiety of ketolides is reported. This deprotection method is applicable to the synthesis of a variety of ketolide analogues with various 9-iminoether moieties in good to moderate yield. Among...
Saved in:
Published in | Journal of antibiotics Vol. 58; no. 11; p. 679 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
Nature Publishing Group
01.11.2005
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A simple synthetic method for deprotection of the N- and O-carbobenzoxy groups (Cbz) of the desosamine sugar moiety of ketolides is reported. This deprotection method is applicable to the synthesis of a variety of ketolide analogues with various 9-iminoether moieties in good to moderate yield. Among the ketolide derivatives prepared by this method, compound 7g with a quinoline-6-yl moiety showed potent activity against erythromycin-resistant pathogens as well as Haemophilus influenzae. |
---|---|
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.1038/ja.2005.93 |