Synthesis of Curcumin Derivatives (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) from Vanillin and Its Activity Test Against Α-Glucosidase Enzymes

• Published in: Walisongo journal of chemistry Vol. 5; no. 1; pp. 1 - 9
• Main Authors: Martha, Rahma Diyan, Danar, Danar, Retnosari, Rini
• Format: Journal Article
• Language: English
• Published: Department of Chemistry, Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang 15.07.2022
• Subjects: curcumin; cyclopentanone; vanillin; α-glucosidase enzymes
• ISSN: 2549-385X; 2621-5985
• DOI: 10.21580/wjc.v5i1.8905

Synthesis of curcumin analogs (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) based on Claisen-Schmidt condensation using an acid catalyst and inhibition of glucosidase enzyme was carried out. The antidiabetic activity of curcumin analogs was carried out by the use of α-glucosidase enzyme from moldy rice (Oryza sativa). The curcumin analogs were synthesized by reacting the vanillin with cyclopentanone.  The structure of all products was confirmed by FTIR, GC-MS, 1H-13C-NMR spectrometers, and the activity enzyme. The results showed the curcumin analogs were yielded in 52.27%, respectively as yellowish-green solid. The inhibition test of the α-glucosidase enzyme showed that the curcumin analogs were the potential to inhibit the α-glucosidase enzyme with an inhibition percentage of about 94.26% in 5 mM.