AB0768 NEUROLOGICAL MANIFESTATIONS IN GRANULOMATOSIS WITH POLYANGIITIS: ABOUT 11 CASES

• Published in: Annals of the rheumatic diseases Vol. 80; no. Suppl 1; pp. 1410 - 1411
• Main Authors: Jomaa, O., Berriche, O., Arfa, S., Fraj, A., Belkhiri, M., Makhloufi, R., Romdhane, W., Hermassi, M.
• Format: Journal Article
• Language: English
• Published: 01.06.2021
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2021-eular.1660

Background: Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis, affecting mainly the superior airways, lungs and kidneys. Neurological impairment is frequent, described in 22 to 54% of cases, and rarely inaugurates the disease. Objectives: The objective of our work was to evaluate its prevalence and its different aspects. Methods: A retrospective study including 11 files of GPA patients followed over a period of 10 years in The Internal Medecine Department at Tahar Sfar Hospital Mahdia TUNISIA. Results: Neurological manifestations were reported in 5 patients: a pyramidal syndrome was noted in 3 patients with a normal cerebral MRI, a disabled headache was described in one patient with a normal cerebral MRI. Peripheral neuropathy in 2 cases, and the Electroneuromyogram objectified a mononeuropathy affecting the ulnar nerve, peroneal nerve, and musculocutaneous nerve in one patient and a distal sensitivomotor poly neuropathy in one patient. Cranial nerves damage was noted in two cases, one VII (1 case) and one V (1 case). Conclusion: Our study results, show the importance of timely diagnosis of these neurological manifestations, as their evolution will depend on the early GPA treatment. References: [1]doi: 10.1016/j.autrev.2017.07.007 Disclosure of Interests: None declared