ALDH 2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 3; pp. 1666 - 1674
• Main Authors: Li, Yan‐yan, Wang, Hui, Wu, Jing‐jing, Kim, Hyun Jun, Yang, Xin‐xing, Geng, Hong‐yu, Gong, Ge
• Format: Journal Article
• Language: English
• Published: Chichester John Wiley & Sons, Inc 01.03.2018
• Subjects: Aldehyde dehydrogenase; Aldehyde dehydrogenase (NAD); Alleles; Cardiovascular disease; Coronary artery; Coronary vessels; Gene polymorphism; Heart diseases; Meta-analysis; Mitochondria; Population genetics; Beijing China; China
• ISSN: 1582-1838; 1582-4934
• DOI: 10.1111/jcmm.13443

Several studies indicate the mitochondrial Aldehyde Dehydrogenase‐2 ( ALDH 2) gene G487A polymorphism may be correlated with coronary artery disease ( CAD ) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH 2 gene G487A polymorphism and CAD within the Chinese population, a meta‐analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios ( OR s) and their corresponding 95% confidence intervals were assessed using random or fixed‐effect models depending the heterogeneity existence or not. Our meta‐analysis found a significant association between ALDH 2 gene G487A polymorphism and CAD in the Chinese population under allele ( OR : 1.830, 95% CI : 1.560–2.140, P = 1.36 × 10 −13 ), recessive ( OR : 1.920, 95% CI : 1.530–2.390, P = 1.20 × 10 −8 ), dominant ( OR : 1.593, 95% CI : 1.336–1.900, P = 2.22 × 10 −7 ), homozygous ( OR : 2.280, 95% CI : 1.810–2.870, P = 3.17 × 10 −12 ) and heterozygous genetic models ( OR : 3.330, 95% CI : 2.070–5.370, P = 7.81 × 10 −7 ). The positive correlation between the ALDH 2 gene G487A polymorphism and CAD makes the mutation a strong candidate as a genetic risk marker for CAD . Through further analysis, we also found that A allele carriers of ALDH 2 gene G487A polymorphism may be particularly susceptible to CAD .