SNPs typing based on the formation of fluorescent signaling DNA aptamers which bind to bile acids

A simple and rapid method for the detection of single nucleotide polymorphisms (SNPs) is essential for the development of personalized medicine because SNPs correlate with some diseases and side effects of some drugs. Here we report a new method for the fluorescent detection of single nucleotide mut...

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Bibliographic Details
Published inNucleic Acids Symposium Series Vol. 51; no. 1; pp. 97 - 98
Main Authors Kato, Teru, Kamoto, Saori, Hyuga, Masumi, Karube, Isao
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.11.2007
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Summary:A simple and rapid method for the detection of single nucleotide polymorphisms (SNPs) is essential for the development of personalized medicine because SNPs correlate with some diseases and side effects of some drugs. Here we report a new method for the fluorescent detection of single nucleotide mutations that is based on the formation of cholic-acid binding DNA aptamers which form fully matched three-way junctions.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrm049