Roles of ST 2, IL ‐33 and BNP in predicting major adverse cardiovascular events in acute myocardial infarction after percutaneous coronary intervention

• Published in: Journal of cellular and molecular medicine Vol. 21; no. 11; pp. 2677 - 2684
• Main Authors: Wang, Yan‐Peng, Wang, Jian‐Hua, Wang, Xiao‐Long, Liu, Jun‐Yi, Jiang, Fang‐Yun, Huang, Xiao‐Li, Hang, Jing‐Yu, Qin, Wei, Ma, Shi‐Xin, Zhang, Jie, Yuan, Min‐Jie, Li, Jing‐Bo, Lu, Zhi‐Gang, Wei, Meng
• Format: Journal Article
• Language: English
• Published: Chichester John Wiley & Sons, Inc 01.11.2017
• Subjects: Angioplasty; Coronary artery; Correlation analysis; Enzyme-linked immunosorbent assay; Health risk assessment; Heart attacks; Myocardial infarction; Regression analysis; Risk factors; Serum levels; Survival
• ISSN: 1582-1838; 1582-4934
• DOI: 10.1111/jcmm.13183

Abstract This study investigated roles of serum ST 2, IL ‐33 and BNP in predicting major adverse cardiovascular events ( MACE s) in acute myocardial infarction ( AMI ) after percutaneous coronary intervention ( PCI ). Blood samples were collected from the included AMI patients ( n  = 180) who underwent PCI . All patients were divided into the MACE s and MACE s‐free groups. Enzyme‐linked immunosorbent assay was performed to measure serum levels of ST 2, IL ‐33 and BNP . Severity of coronary artery lesion was evaluated by Gensini score. Pearson correlation analysis was used. A receiver operating characteristics curve was drawn to evaluate the potential roles of ST 2, IL ‐33 and BNP in predicting MACE s, and Kaplan–Meier curve to analyse the 1‐year overall survival rate. Logistic regression analysis was conducted to analyse the independent risk factors for MACE s. Compared with the MACE s‐free group, the serum levels of ST 2, IL ‐33 and BNP were significantly higher in the MACE s group. Serum levels of ST 2, IL ‐33 and BNP were positively correlated with each other and positively correlated with Gensini score. The area under curves of ST 2, IL ‐33 and BNP , respectively, were 0.872, 0.675 and 0.902. The relative sensitivity and specificity were, respectively, 76.27% and 85.92%, 69.49% and 58.68%, as well as, 96.61% and 77.69%. Serum levels of ST 2, IL ‐33 and BNP were independent risk factors for MACE s. The 1‐year overall survival rate was higher in AMI patients with lower serum levels of ST 2, IL ‐33 and BNP . In conclusion, serum levels of ST 2, IL ‐33 and BNP have potential value in predicting MACE s in AMI patients undergoing PCI .