Six noreudesmane sesquiterpenoids from Dobinea delavayi and their lipid-lowering and antimalarial activities

• Published in: Journal of molecular structure Vol. 1321; p. 140066
• Main Authors: Dong, Li-Tian, Chen, Wei, He, Pei-Mi, Sun, He, Liu, Bo-Chao, Zhao, Xuan, Liu, Rong, Shen, Lei, Jiang, Bei, Xiao, Chao-Jiang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.02.2025
• Subjects: Anacardiaceae; Antimalarial activities; Chemical constituents; Dobinea delavayi; Isolation and identification; Lipid-lowering; Noreudesmane sesquiterpenoids; Chemical constituents; Isolation and identification; Dobinea delavayi; Antimalarial activities; Lipid-lowering; Anacardiaceae; Noreudesmane sesquiterpenoids
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.140066

•Dobinin V is the first example of 7,8-seco-11,12,13-trinoreudesmane sesquiterpenoid in nature.•A possible biosynthetic pathway of dobinins V−Z, and AA is proposed.•Lipid-lowering activity of eudesmane sesquiterpenoids was first discovered.•Dobinin AA showed significant in vitro lipid-lowering activity.•Dobinins X and Y showed moderate in vitro antimalarial activities. Six undescribed noreudesmane sesquiterpenoids (dobinins V-Z, and AA; 1–6) were isolated from Dobinea delavayi, including 1 as the first example of 7,8-seco-11,12,13-trinoreudesmane sesquiterpenoids with a unique skeleton fusing by a cyclohexane and a six-membered lactone. NMR and HR-ESI-MS spectroscopies were used to identify the structures of dobinins V-Z, and AA, and single-crystal X-ray diffraction experiment was conducted to verify the structure of dobinin V. A biosynthetic pathway of dobinins V-Z, and AA was suggested based on the structure. The isolated compounds were tested in vitro for lipid-lowering activity and for antimalarial activity against Plasmodium falciparum 3D7. Eudesmane sesquiterpenoids were discovered to have lipid-lowering activity for the first time. [Display omitted]