SMALL GTPASE ARF6 ACTIVATES mTORCl-DEPENDENT SIGNALING PATHWAY AND STIMULATES GLIOBLASTOMA CELL GROWTH

In this study we first identified role of small GTPase Arf6 in stimulation of proliferation and autonomous growth of human glioblastoma cells. We revealed that Arf6 activates the mTOR complex 1 (mTORCl) and this process is appeared to be an alternative mechanism of mTORC1-signaling activation, indep...

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Bibliographic Details
Published inRussian Journal of Biotherapy Vol. 14; no. 2; pp. 91 - 98
Main Authors Zhuravskaya, A. Yu, Komelkov, A. V., Tchevkina, E. M.
Format Journal Article
LanguageEnglish
Published 30.06.2015
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Summary:In this study we first identified role of small GTPase Arf6 in stimulation of proliferation and autonomous growth of human glioblastoma cells. We revealed that Arf6 activates the mTOR complex 1 (mTORCl) and this process is appeared to be an alternative mechanism of mTORC1-signaling activation, independent of PI3K/Akt-signaling pathway. We also showed that Arf6 is a negative regulator of protein kinase ERK1/2 in glioblastoma cells.
ISSN:1726-9784
DOI:10.17650/1726-9784-2015-14-2-91-98