Site-Selective Defluorinative sp 3 C-H Alkylation of Secondary Amides

A site-selective defluorinative sp C-H alkylation of secondary amides that rapidly and reliably incorporates -difluoroalkene motifs into previously unfunctionalized sp sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlockin...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 143; no. 17; pp. 6395 - 6400
Main Authors Yue, Wen-Jun, Day, Craig S, Martin, Ruben
Format Journal Article
LanguageEnglish
Published United States 05.05.2021
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Summary:A site-selective defluorinative sp C-H alkylation of secondary amides that rapidly and reliably incorporates -difluoroalkene motifs into previously unfunctionalized sp sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.1c03126