Site-Selective Defluorinative sp 3 C-H Alkylation of Secondary Amides
A site-selective defluorinative sp C-H alkylation of secondary amides that rapidly and reliably incorporates -difluoroalkene motifs into previously unfunctionalized sp sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlockin...
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Published in | Journal of the American Chemical Society Vol. 143; no. 17; pp. 6395 - 6400 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
05.05.2021
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Online Access | Get full text |
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Summary: | A site-selective defluorinative sp
C-H alkylation of secondary amides that rapidly and reliably incorporates
-difluoroalkene motifs into previously unfunctionalized sp
sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites. |
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ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/jacs.1c03126 |