Isoquinoline alkaloids fromMahonia aquifolium stem bark are active againstMalassezia spp

Bioassay directed fractionation of crude extract fromMahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal ac...

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Published inFolia microbiologica Vol. 46; no. 2; pp. 107 - 111
Main Authors Volleková, A., Košťálová, D., Sochorová, R.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Nature B.V 01.04.2001
Subjects
Alkaloids
Antifungal activity
Berberine
Bioassays
Bisbenzylisoquinoline
Fractionation
Fungi
Fungicides
Iodides
Microbiology
Stems
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Summary:Bioassay directed fractionation of crude extract fromMahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI fromM. aquifolium stem bark were evaluated against six strains ofMalassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range ≤50–≥1000 mg/L.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02873586