The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure

• Published in: Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки Vol. 23; no. 101; pp. 93 - 99
• Main Authors: Varkholiak, I. S., Gutyj, B. V.
• Format: Journal Article
• Language: English
• Published: Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv 05.04.2021
• Subjects: pharmacology, bendamin, heart failure, cardiomyopathy, dogs
• ISSN: 2518-7554; 2518-1327
• DOI: 10.32718/nvlvet10116

Experimental studies obtained in recent years indicate the urgency of developing drugs of complex action to prevent the development of cardiovascular disease in dogs. This requires a much deeper study of the pathogenesis of heart failure, including cardiomyopathy. The aim of the study was to investigate the effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure. Two groups of dogs were formed for research: control (healthy) and experimental (sick). The 30-day experiment included 10 dogs of the control group and 10 dogs of the experimental (sick) breed of spaniel and dog 10–12 years of age. Treatment regimen for sick dogs: furosemide was administered orally on an empty stomach at 2 mg/kg every 12 hours; enalapril was administered orally at 0.5 mg/kg every 12 hours; bendamine was administered orally on an empty stomach at 20 mg/kg every 24 hours. It is recommended to divide the dose into two doses. An increase in the activity of aminotransferases (ALT by 59.2 %, AST – by 51.9 %) was found in the serum of dogs at heart failure. An increase in alkaline phosphatase activity was also found, which in the complex is an additional confirmation of changes in the heart muscle. Lactate dehydrogenase activity increased in the blood of sick dogs by 23.5 %. Minor changes in the content of total bilirubin and urea in the serum of sick dogs indicate the initial stage of liver pathology with impaired liver function due to congestion in the small circulation. This is also indicated by a decrease in the level of total protein in the blood of sick dogs, which was respectively 57.2 ± 3.57 g/l against the control group of 63.5 ± 4.15 g/l. On the basis of cardiac dysfunction and on the background of congestion, the function of not only the liver but also the kidneys is impaired (the so-called cardiorenal syndrome in heart failure). This is indicated by an increase in urea and creatinine by 38.5 and 36.9 %, respectively, compared with animals in the control group. The use of the drug “Bendamin” alleviated the manifestations of functional failure of the heart, liver and kidneys, as indicated by biochemical studies. Studies confirm the feasibility of using the drug “Bendamin” in dogs with the development of heart failure. The use of the drug “Bendamine” in patients with heart failure in dogs had a positive effect on the restoration of hematopoiesis and the normalization of biochemical parameters of the blood.