New acid anhydride from Phalaris canariensis with antimicrobial activity assessed through in vitro and in silico approaches

In this study, a novel fatty acid anhydride, named phalarisin 1, was successfully isolated from the ethyl acetate extract of growing in Tunisia. The structural characterisation of the compound was achieved through various spectroscopic techniques including FT-IR, 1D and 2D-NMR spectroscopy, as well...

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Published inNatural product research pp. 1 - 7
Main Authors Kchaou, Mouna, Soltani, Siwar, Frikha, Donyez, Maalej, Sami, Allouche, Noureddine, Ben Salah, Hichem
Format Journal Article
LanguageEnglish
Published England 14.10.2024
Subjects
Phalaris canariensis
Antimicrobial activity
molecular docking study
fatty acid anhydride
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Summary:In this study, a novel fatty acid anhydride, named phalarisin 1, was successfully isolated from the ethyl acetate extract of growing in Tunisia. The structural characterisation of the compound was achieved through various spectroscopic techniques including FT-IR, 1D and 2D-NMR spectroscopy, as well as acidic hydrolysis analyses. Remarkably, phalarisin exhibited potent antimicrobial properties against a range of pathogens including , , , and , with minimum inhibitory concentrations (MICs) ranging from 31.25 to 62.5 μg/mL. To grasp the antimicrobial potential of compound 1, molecular docking studies were performed and they furnished evidence indicating its ability to bind to proteins in bacteria and fungi that are pivotal for drug resistance.
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ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2024.2414398