Health state utility is substantially reduced with an increasing burden of patient-reported symptoms in eosinophilic esophagitis

We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters. In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index (EEsAI). In 5...

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Bibliographic Details
Published inThe American journal of gastroenterology
Main Authors Cotton, Cary C, Biswas, Mousumi, Dellon, Evan S
Format Journal Article
LanguageEnglish
Published United States 27.09.2024
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Summary:We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters. In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index (EEsAI). In 51 adults with EoE, mean utility was 0.91 (95% CI 0.86, 0.95). Utility was numerically worse in patients with dilation or a smaller stricture diameter. With each ten-point improvement in EEsAI, utility increased by 0.03 (95% CI 0.01, 0.05). EoE is associated with reduced health state utility, with symptoms most strongly predicting valuation.
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ISSN:0002-9270
1572-0241
1572-0241
DOI:10.14309/ajg.0000000000003106