Correction of endotoxemia in patients with pancreatic necrosis

To study the results of deferoxamine (Deferal) administration in intensive therapy program of 63 patients with severe acute pancreatitis to decrease effect of oxidative stress and endotoxemia. In deferoxamine group (31 patients) there were decrease of serum iron's level and inhibition of free r...

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Published inHirurgija (Moskva) no. 10; p. 36
Main Authors Orlov, Yu P, Ershov, A V, Lukach, V N, Govorova, N V, Degovtsov, E N, Glushchenko, A V
Format Journal Article
LanguageEnglish
Russian
Published Russia (Federation) 2015
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Summary:To study the results of deferoxamine (Deferal) administration in intensive therapy program of 63 patients with severe acute pancreatitis to decrease effect of oxidative stress and endotoxemia. In deferoxamine group (31 patients) there were decrease of serum iron's level and inhibition of free radical oxidation that led to early relief of endotoxemia, reducing periods of organs' dysfunction. It was not observed in comparison group (32 patients). Deferoxamine decrease risk of pancreatic necrosis and pancreatogenic sepsis. It allows reducing ICU- and hospital-stay and number of extended surgical procedures.
ISSN:0023-1207
DOI:10.17116/hirurgia20151036-42