P073 MESENCHYMAL STEM/STROMAL CELLS REGULATE GUT INFLAMMATION AND INFECTION VIA IL-33 PRODUCTION

• Published in: Inflammatory bowel diseases Vol. 24; no. suppl_1; pp. S26 - S27
• Main Authors: Mahlakõiv, Tanel, Bryce, Paul, Artis, David
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 18.01.2018
• Subjects: Crohn's disease; Cytokines; Dendritic cells; Feces; Gastroenterology; Infections; Inflammation; Inflammatory bowel disease; Kinases; Neutrophils; Permeability; Protein expression; Proteins; Stem cells

Abstract Interleukin (IL-)33 is a cytokine that possesses dichotomous functions in the gut. Whereas various cell types have been reported to produce IL-33, conventionally it is believed to be released from damaged intestinal epithelial cells. Many cell types express the ST2 receptor complex and resp...