Association of low PAPP-A with the timing of delivery in babies with IUGR, babies showing suboptimal growth on serial scans, and well-grown babies
Background: The ideal timing for delivering babies with pre-eclampsia or small for gestational age is clear. There is agreement on delivering babies with pre-eclampsia and small for gestational age, but not for normally growing babies with low PAPP-A. Aim was to study the association of low pappa wi...
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Published in | International journal of reproduction, contraception, obstetrics and gynecology Vol. 13; no. 10; pp. 2851 - 2856 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
26.09.2024
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Online Access | Get full text |
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Summary: | Background: The ideal timing for delivering babies with pre-eclampsia or small for gestational age is clear. There is agreement on delivering babies with pre-eclampsia and small for gestational age, but not for normally growing babies with low PAPP-A. Aim was to study the association of low pappa with adverse pregnancy outcomes and ideal delivery timing in a well-grown baby with low pappa as a risk factor. Methods: A retrospective study analyzed 3240 singleton pregnancies with first-trimester Down syndrome screening at local hospitals from January 2022 to April 2023. Among these, 130 singleton pregnancies had PAPP-A levels at the 5th centile, along with risk estimations and documentation. Results: In NCIC Trust births, 3280 women were assessed for low PAPP-A. Of these, 130 had low PAPP-A levels. It revealed that 46.9% used aspirin, with a high down screen risk found in 11.5%. In this study, 13.1% experienced PIH. 2 resulted in intrauterine fetal death (1.5%). 9 women (6.9%) experienced pre-term births. The study identified 8 newborns (6.25%) with birth weights below the 10th centile after >39+6 weeks, and 6 (4.6%) <3rd centile after 37+6 weeks. Conclusions: The study linked low PAPP-A to poor APGAR scores, stillbirth, growth issues, and special care unit admissions. Babies with low PAPP-A showed higher morbidity and mortality after 41 weeks. The findings indicate that delivery should occur between 40+0 and 40+6 weeks. Further research is needed to create an antenatal protocol for optimal delivery timing for babies with low PAPP-A. |
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ISSN: | 2320-1770 2320-1789 |
DOI: | 10.18203/2320-1770.ijrcog20242822 |