FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity

Tumor induced osteomalacia is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Patients complain of progressive bone pain, muscle weakness and brittle fractures. Delayed diagnosis of osteomalacia caused by a tumor is often found in clinica...

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Published inVestnik otorinolaringologii Vol. 88; no. 6; p. 91
Main Authors Ovchinnikov, A Yu, Khon, E M, Bakotina, A V, Miroshnichenko, N A, Gronskaia, S A, Belaya, Zh E
Format Journal Article
LanguageRussian
Published Russia (Federation) 2023
Subjects
Ear, Middle - pathology
Humans
Neoplasms, Connective Tissue - diagnosis
Neoplasms, Connective Tissue - etiology
Neoplasms, Connective Tissue - surgery
Osteomalacia - diagnosis
Osteomalacia - etiology
Paraneoplastic Syndromes - complications
Paraneoplastic Syndromes - etiology
osteomalacia
hypophosphatemia
phosphaturic mesenchymal tumor
fibroblast growth factor 23
tumor
phosphorus
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Summary:Tumor induced osteomalacia is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Patients complain of progressive bone pain, muscle weakness and brittle fractures. Delayed diagnosis of osteomalacia caused by a tumor is often found in clinical practice. When verifying the exact localization of the neoplasm, radical removal within healthy tissues is recommended. The article considers a clinical example of FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity.
ISSN:0042-4668
DOI:10.17116/otorino20238806191