Effects of gonadotropins in female infertility associated with depression

• Published in: Buletin de psihiatrie integrativa Vol. 87; no. 4; pp. 77 - 84
• Main Authors: Barbu, Roxana Mihaela, Gavrilescu, Cristina-Maria, Stana, Bogdan, Popescu, Raducu I, Pohaci-Antonesei, Cătălin, Bild, Walther
• Format: Journal Article
• Language: English
• Published: Editura Sedcom Libris Iasi 24.12.2020; Sedcom Libris Publishing House Iasi
• Subjects: Health and medicine and law; depression; luteinizing hormone; infertility; Folliclestimulating hormone
• ISSN: 2393-2694; 1453-7257; 2393-2694
• DOI: 10.36219/BPI.2020.4.08

Introduction: The relationship between LH and FSH changes and mental health is not clear yet, but may be independent of a strict diagnosis of infertility. Ongoing research has suggested that testosterone levels may play a role in brain development, which could provide a possible explanation for this association. Healthcare providers caring for women with infertility need to be aware that their patients may face many challenges when faced with infertility, such as depression. An in-depth assessment of the psychiatric needs of patients with infertility is crucial to provide specialized care to this category of patients. The aim of the study was to observe the possible implications of FSH and LH hormones in infertility and associated depression through studying the hormone levels in two Swiss mice groups and to compare these findings to the current literature. Materials and Methods: We used 20 Swiss nulliparous female mice and 15 Swiss multiparous female mice and we measured the luteinizing hormone and follicle-stimulating hormone in each group. Results: We observed a significant increase in mean LH and FSH in the multiparous group compared to the nulliparous group. In conclusion, significant differences in LH and FSH în the multiparous group compared to the nulliparous group and the presence of variations between the two groups of the studied mice suggest that a decrease in LH and FSH in nulliparous females could cause infertility that could also be associated with depression.