Traitement antiagrégant plaquettaire chez la femme : une spécificité liée au sexe ?

La femme est un sous-groupe de patients fragile et complexe, sous-représenté dans les études cliniques, mais qui subit un nombre croissant d’évènements cardiovasculaires, avec une plus forte mortalité, une présentation retardée, un plus fort taux de complications hémorragiques et un sous traitement...

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Published inAnnales de cardiologie et d'angéiologie Vol. 65; no. 6; pp. 395 - 403
Main Author Bellemain-Appaix, A.
Format Journal Article
LanguageFrench
Published Elsevier SAS 01.12.2016
Subjects
Antiagrégant plaquettaire
Antiplatelet therapy
Aspirin
Aspirine
Clopidogrel
Femme
Gender
Genre
Grossesse
Prasugrel
Pregnancy
Ticagrelor
Women
Women
Aspirin
Antiagrégant plaquettaire
Gender
Aspirine
Femme
Prasugrel
Antiplatelet therapy
Pregnancy
Grossesse
Clopidogrel
Genre
Ticagrelor
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Abstract La femme est un sous-groupe de patients fragile et complexe, sous-représenté dans les études cliniques, mais qui subit un nombre croissant d’évènements cardiovasculaires, avec une plus forte mortalité, une présentation retardée, un plus fort taux de complications hémorragiques et un sous traitement anti-thrombotique comparativement à leurs homologues masculins. Le genre féminin a été associé à une plus forte réactivité plaquettaire basale, une forte réactivité plaquettaire sous traitement, et à des réponses variées aux agents antiplaquettaires. Une préoccupation croissante sur les spécificités liées au sexe à émergé, incluant les différences potentielles entre femmes et hommes dans les bénéfices et les risques des traitements antiplaquettaires en prévention primaire et secondaire, et selon l’agent antiplaquettaire employé. Nous fournissons ici une revue des données disponibles sur le traitement antiplaquettaire chez la femme. Women is a fragile and complex substet of patients, under-represented in clinical trials, but experiencing growing cardiovascular events, with higher mortality, delayed presentation, higher bleeding complications and undertreatment with antithrombotic therapies, compared to their male counterparts. Female gender has been associated with enhanced basal platelet reactivity, high residual on-treatment platelet reactivity and various responses to antiplatelet agents. Growing concern on gender-specificity has emerged, including potential difference in women compared with men on the benefits and risks of antiplatelet therapy in primary or secondary prevention and according the antiplatelet agent used. We provide here a review of available data on antiplatelet therapy in women.
AbstractList La femme est un sous-groupe de patients fragile et complexe, sous-représenté dans les études cliniques, mais qui subit un nombre croissant d’évènements cardiovasculaires, avec une plus forte mortalité, une présentation retardée, un plus fort taux de complications hémorragiques et un sous traitement anti-thrombotique comparativement à leurs homologues masculins. Le genre féminin a été associé à une plus forte réactivité plaquettaire basale, une forte réactivité plaquettaire sous traitement, et à des réponses variées aux agents antiplaquettaires. Une préoccupation croissante sur les spécificités liées au sexe à émergé, incluant les différences potentielles entre femmes et hommes dans les bénéfices et les risques des traitements antiplaquettaires en prévention primaire et secondaire, et selon l’agent antiplaquettaire employé. Nous fournissons ici une revue des données disponibles sur le traitement antiplaquettaire chez la femme. Women is a fragile and complex substet of patients, under-represented in clinical trials, but experiencing growing cardiovascular events, with higher mortality, delayed presentation, higher bleeding complications and undertreatment with antithrombotic therapies, compared to their male counterparts. Female gender has been associated with enhanced basal platelet reactivity, high residual on-treatment platelet reactivity and various responses to antiplatelet agents. Growing concern on gender-specificity has emerged, including potential difference in women compared with men on the benefits and risks of antiplatelet therapy in primary or secondary prevention and according the antiplatelet agent used. We provide here a review of available data on antiplatelet therapy in women.
Author Bellemain-Appaix, A.
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Issue 6
Keywords Women
Aspirin
Antiagrégant plaquettaire
Gender
Aspirine
Femme
Prasugrel
Antiplatelet therapy
Pregnancy
Grossesse
Clopidogrel
Genre
Ticagrelor
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PublicationTitle Annales de cardiologie et d'angéiologie
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Snippet La femme est un sous-groupe de patients fragile et complexe, sous-représenté dans les études cliniques, mais qui subit un nombre croissant d’évènements...
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SubjectTerms Antiagrégant plaquettaire
Antiplatelet therapy
Aspirin
Aspirine
Clopidogrel
Femme
Gender
Genre
Grossesse
Prasugrel
Pregnancy
Ticagrelor
Women
Title Traitement antiagrégant plaquettaire chez la femme : une spécificité liée au sexe ?
URI https://dx.doi.org/10.1016/j.ancard.2016.10.008
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