Neuromyelitis optica and neuromyelitis optica spectrum disorders

The review is devoted to up-to-date data on epidemiology, aspects of the pathogenesis of neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD). The authors consider a role of myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) in the syndromes phenotypically simil...

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Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 119; no. 10. Vyp. 2; p. 35
Main Authors Simaniv, T O, Vasiliev, A V, Askarova, L Sh, Zakharova, M N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2019
Subjects
Autoantibodies - analysis
Autoantibodies - immunology
Humans
Immunoglobulin G - immunology
Myelin-Oligodendrocyte Glycoprotein - immunology
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - immunology
Neuromyelitis Optica - pathology
treatment
myelin oligodendrocyte glycoprotein immunoglobulin G antibodies
aquaporin-4 immunoglobulin G antibodies
demyelinating diseases
neuromyelitis optica spectrum disorders
neuromyelitis optica
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Summary:The review is devoted to up-to-date data on epidemiology, aspects of the pathogenesis of neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD). The authors consider a role of myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) in the syndromes phenotypically similar to NMO and NMOSD. Special attention is drawn to the methods of MOG-IgG antibodies detection and indications for testing. The approaches and management for treatment and prevention of NMO relapses, risks of complications during pregnancy and immediately after delivery, as well as methods for their prevention and treatment, are described.
ISSN:1997-7298
DOI:10.17116/jnevro201911910235